2k is going to be more durable than a spray can. Not sure what your asking?
can i use a spray can to bring color on a 2k clear coated mold?
Are you wanting to clear a mold then add spray paint over top? That might work or just buy a 2k paint.
I've had good luck with shop line ppg clear coats....
Safety.... You need gloves, respirator, and a well ventlated area, or paint outside.